To determine what patient characteristics and healthcare use patterns are associated with adherence to treatment for alcohol use disorders, researchers analyzed pharmacy records over 6 months from a nationally distributed treatment population to determine prescription adherence* to oral naltrexone. They then measured patient characteristics and health services utilization associated with adherence.


* Defined as having filled prescriptions ≥80% of the time over the 6-month review period.

Commentary by Michael G. Boyle, MA
Nonadherence with medications is common. Many of us have not completed a full course of antibiotic treatment after filling the prescription. Yet, the very high rate of nonadherence to naltrexone in this study suggests that clinicians should learn and apply evidence-based psychosocial interventions (e.g., the community reinforcement approach, couples behavioral treatment) with an increased focus on medication adherence as a component, and also take into account the higher risk of nonadherence associated with some demographic factors.